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FOSB proteins in th...
FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics
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- Watanabe, Hiroyuki (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Henriksson, Richard (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Ohnishi, Yoshinori N. (author)
- Department of Neuroscience, Mount Sinai School of Medicine, New York, USA
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- Ohnishi, Yoko H. (author)
- Department of Neuroscience, Mount Sinai School of Medicine, New York, USA
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- Harper, Clive (author)
- Discipline of Pathology, University of Sydney, Sydney, Australia
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- Sheedy, Donna (author)
- Discipline of Pathology, University of Sydney, Sydney, Australia
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- Garrick, Therese (author)
- Discipline of Pathology, University of Sydney, Sydney, Australia
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- Nyberg, Fred (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Nestler, Eric J. (author)
- Department of Neuroscience, Mount Sinai School of Medicine, New York, USA
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Yakovleva, Tatjana (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: Addiction Biology. - : Wiley. - 1355-6215 .- 1369-1600. ; 14:3, s. 294-297
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Abstract
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- The transcription factor DeltaFosB is accumulated in the addiction circuitry, including the orbitofrontal and medial prefrontal cortices of rodents chronically exposed to ethanol or other drugs of abuse, and has been suggested to play a direct role in addiction maintenance. To address this hypothesis in the context of substance dependence in humans, we compared the immunoreactivities of FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices (OFC and DLPFC respectively) between controls and alcoholics using semiquantitative immunoblotting. In both structures, we detected three forms of FOSB, one of which was DeltaFOSB, but in neither case did their immunoreactivities differ between the groups. Our results indicate that the DeltaFOSB immunoreactivity in the human brain is very low, and that it is not accumulated in the OFC and DLPFC of human alcoholics, suggesting that it may not be directly involved in addiction maintenance, at least not in ethanol dependence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Alcoholics
- dorsolateral prefrontal cortex
- ethanol dependence
- Delta FOSB
- FOSB
- orbitofrontal cortex
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Watanabe, Hiroyu ...
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Henriksson, Rich ...
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Ohnishi, Yoshino ...
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Ohnishi, Yoko H.
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Harper, Clive
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Sheedy, Donna
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Garrick, Therese
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Nyberg, Fred
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Nestler, Eric J.
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Bakalkin, Georgy
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Yakovleva, Tatja ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Addiction Biolog ...
- By the university
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Uppsala University
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Karolinska Institutet